My Friend, Artist Dale Crum

Artist Dale Crum

I’ve been chatting with Steve Day, VP of Marketing at Cheetah Technologies – and I thought of this piece, done by my good friend, Artist Dale Crum.

Dale is available to design anything at all that you need, and the more striking you need it, the better. Dale can be reached at 901-552-8213, or on Twitter @DaleCrum77.

View his LinkedIn profile at http://www.linkedin.com/pub/dale-crum/14/462/873.

Conjunction of planets?

I am out with the kids on the evening of May 26, to see the conjunction of planets (this is the best night to see this). There has not been a cloud in the sky all day, until just recently, when the only clouds that have appeared all day have shown up in the west.

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One year ago today, Beth had her stem cell transplant

On December 14, 2011, my wife, half-dead from a fight with leukemia, “intensive chemotherapy” and full-body radiation, received a new infusion of adult stem cells from a young female donor in Europe. She became radically sick – somehow she got hold of a MRSA infection in her blood; later she had other viral infections that nearly cost her life. She spent the better part of three months in the hospital. You can read more about this struggle in the pages below.

She is still weak, and doesn’t have the energy to do much at all. Her immune system perceives her body as “foreign”, and so she is still taking some anti-rejection medications, which keep the immune system suppressed. So she’s still susceptible to pneumonia and other infections. She is looking forward with great anticipation to celebrating Christmas with her family. In another few months, they’ll start to give her the full cycle of baby vaccinations.

In a series of “Chimerism” tests which measure the level of the donor’s DNA vs her own DNA in her blood cells, she has consistently been “100% donor in all three cell lines”. That indicates no sign that the leukemia is coming back. The longer she shows such results, the closer she comes to being declared “cured” (a happy event which happens after two years).

The best news of all is that, over the last year, she has come to a new understanding of how the Lord Jesus Christ saves us in spite of anything else we might do to help or hurt that process, and is becoming deeply engaged in the life of our church.

Again, I’d like to thank all of you who helped us through this very demanding time with your prayers and your support.

Beth’s donor has signed, and we now have a transplant schedule

I got a call yesterday afternoon from Renee, the transplant coordinator at West Penn. Beth’s donor has signed all the necessary paperwork, and a date of December 14 has been set for the transplant. That means, working backward from that date, the following schedule has been established:

December 5-7: Outpatient treatment at West Penn’s Medical Short Stay unit. Beth will be treated with a drug called Kepivance, the purpose of which is to prevent “mucositis” – mouth sores – one of the more severe side effects of the chemotherapy drugs that Beth will receive. This is an intravenous treatment.

December 8: Beth will be admitted to West Penn’s “T-7” floor – the Hematology/Oncology (or “hem/onc”) unit.

December 8-12: She’ll receive the “intensive” chemotherapy, also called “conditioning”. She’ll receive two or three intravenous drugs spread out over these five days:

Fludarabine: “It has been unofficially and casually referred to as “AIDS in a bottle” amongst healthcare professionals due to its significant immunosuppresive activity”.

Busulfan: “Currently, its main uses are in bone marrow transplantation, … where it is used as a conditioning drug. Busulfan can control tumor burden but cannot prevent transformation or correct cytogenic abnormalities”. To put this into perspective, the Vidaza that Beth was receiving had two functions: it had a cytotoxic effect – it killed things – but it was also supposed to enable her to make her own blood cells (a thing it never did).

Thymoglobulin: I don’t know if Beth is getting this one; it’s on the transplant sheet that Dr Rossetti gave to us, but Renee yesterday said Beth was getting two chemo drugs. Thymoglobulin “very substantially reduces immune competence in patients with normal immune systems”.

December 13-14: Total Body Irradiation (200 cGy).

The donor will undergo five or six days of Neupogen injections “to move stem cells from bone marrow to peripheral blood”. She will then undergo one or two days worth of “collection” – a four- to six-hour process by which blood will be withdrawn from one arm, will flow through a filtering device (similar to a dialysis machine) that will collect only stem cells, and the remaining blood will be re-infused into the other arm.

The stem cells will then be flown into Pittsburgh, where a (we hope) properly-“conditioned” Beth will be awaiting their arrival. The donor is a young female, and she is not from the United States. That’s all we may know about her at this time. I may have mentioned earlier, that we found three “10/10” matches. This is out of 10 million US-based donors, and an international database of seven million donors. For more information on this, see http://www.marrow.org.

It’s interesting to me that they call this procedure a “transplant” – but really, it’s like a slow motion transplant – a damaged organ (in this case, the bone marrow) is removed, slowly, and a new organ, in the form of stem cells, is “transplanted”, albeit slowly.

Home at last

… After a 12 hour day. We left 7:45, to arrive 8:30, to check in at 9:00. The blood draws — all those 21 vials of blood, actually went very quickly. The bone marrow biopsy, scheduled for 10:00 am, got started around noon.  Beth was back in the room, then we had to wait for the three units (a unit of platelets and two units of A+). All in all, a very long and uneventful day.